The Electronics and Data Acquisition System of the DarkSide Dark Matter Search

It is generally inferred from astronomical measurements that Dark Matter (DM) comprises approximately 27\% of the energy-density of the universe. If DM is a subatomic particle, a possible candidate is a Weakly Interacting Massive Particle (WIMP), and the DarkSide-50 (DS) experiment is a direct search for evidence of WIMP-nuclear collisions. DS is located underground at the Laboratori Nazionali del Gran Sasso (LNGS) in Italy, and consists of three active, embedded components; an outer water veto (CTF), a liquid scintillator veto (LSV), and a liquid argon (LAr) time projection chamber (TPC). This paper describes the data acquisition and electronic systems of the DS detectors, designed to detect the residual ionization from such collisions

Prospective validation of the CLIP score: a new prognostic system for patient with cirrhosis and hepatocellular carcinoma

Prognosis of patients with cirrhosis and hepatocellular carcinoma (HCC) depends on both residual liver function and tumor extension. The CLIP score includes Child-Pugh stage, tumor morphology and extension, serum alfa-fetoprotein (AFP) levels, and portal vein thrombosis. We externally validated the CLIP score and compared its discriminatory ability and predictive power with that of the Okuda staging system in 196 patients with cirrhosis and HCC prospectively enrolled in a randomized trial. No significant associations were found between the CLIP score and the age, sex, and pattern of viral infection. There was a strong correlation between the CLIP score and the Okuda stage, As of June 1999, 150 patients (76.5%) had died. Median survival time was 11 months, overall, and it was 36, 22, 9, 7, and 3 months for CLIP categories 0, 1, 2, 3, and 4 to 6, respectively. In multivariate analysis, the CLIP score had additional explanatory power above that of the Okuda stage. This was true for both patients treated with locoregional therapy or not. A quantitative estimation of 2-year survival predictive power showed that the CLIP score explained 37% of survival variability, compared with 21% explained by Okuda stage. In conclusion, the CLIP score, compared with the Okuda staging system, gives more accurate prognostic information, is statistically more efficient, and has a greater survival predictive power. It could be useful in treatment planning by improving baseline prognostic evaluation of patients with RCC, and could be used in prospective therapeutic trials as a stratification variable, reducing the variability of results owing to patient selection

DarkSide-50, a background free experiment for dark matter searches

The existence of dark matter is inferred from gravitational effects, but its nature remains a deep mystery. One possibility, motivated by considerations in elementary particle physics, is that dark matter consists of elementary particles, such as the hypothesized Weakly Interacting Massive Particles (WIMPs), with mass ~ 100 GeV and cross-section ~ 10−47 cm2, that can be gravitationally trapped inside our galaxy and revealed by their scattering on nuclei. It should be possible to detect WIMPs directly, as the orbital motion of the WIMPs composing the dark matter halo pervading the galaxy should result in WIMP-nucleus collisions of sufficient energy to be observable in the laboratory. The DarkSide-50 experiment is a direct WIMP search using a Liquid Argon Time Projection Chamber (LAr-TPC) with an active mass of 50 kg with a high sensitivity and an ultra-low background detector

The Electronics and Data Acquisition System of the DarkSide Dark Matter Search

It is generally inferred from astronomical measurements th at Dark Matter (DM) comprises approximately 27% of the energy-dens ity of the universe. If DM is a subatomic particle, a possible candidate is a Weakl y Interacting Mas- sive Particle (WIMP), and the DarkSide-50 (DS) experiment i s a direct search for evidence of WIMP-nuclear collisions. DS is located undergr ound at the Laboratori Nazionali del Gran Sasso (LNGS) in Italy, and consists of thr ee active, embedded components; an outer water veto (CTF), a liquid scintillato r veto (LSV), and a liquid argon (LAr) time projection chamber (TPC). This pap er describes the data acquisition and electronic systems of the DS detectors , designed to detect the residual ionization from

First Results from the DarkSide-50 Dark Matter Experiment at Laboratori Nazionali del Gran Sasso

We report the first results of DarkSide-50, a direct search for dark matter operating in the un- derground Laboratori Nazionali del Gran Sasso (LNGS) and searching for the rare nuclear recoils possibly induced by weakly interacting massive particles (WIMPs). The dark matter detector is a Liquid Argon Time Projection Chamber with a ( 46.4 0.7 ) kg active mass, operated inside a 30 t or- ganic liquid scintillator neutron veto, which is in turn installed at the center of a 1 kt water Cherenkov veto for the residual flux of cosmic rays. We report here the null results of a dark matter search for a ( 1422 67 ) kg d exposure with an atmospheric argon fill. This is the most sensitive dark matter search performed with an argon target, corresponding to a 90% CL upper limit on the WIMP-nucleon spin-independent cross section of 6.1 1